Počet záznamov: 1
Synthesis and free radical scavenging activity of new hydroxybenzylidene hydrazines
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$a 10.3390/molecules22060894 $2 DOI 100 $a 20171114 2017 m y slo 03 ba 101 0-
$a eng 102 $a CH 200 1-
$a Synthesis and free radical scavenging activity of new hydroxybenzylidene hydrazines $f František Šeršeň ... [et al.] 330 $a Hydroxybenzylidene hydrazines exhibit a wide spectrum of biological activities. Here, we report synthesis and free radical scavenging activity of nine new N-(hydroxybenzylidene)-N'-[2,6-dinitro-4-(trifluoromethyl)]phenylhydrazines. The chemical structures of these compounds were confirmed by H-1-NMR, C-13-NMR, F-19-NMR, IR spectroscopy, LC-MS, and elemental analysis. The prepared compounds were tested for their activity to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR), and 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The free radical scavenging activity expressed as SC50 values of these compounds varied in a wide range, from a strong to no radical scavenging effect. The most effective radical scavengers were hydroxybenzylidene hydrazines containing three hydroxyl groups in the benzylidene part of their molecules. The prepared compounds were also tested for their activity to inhibit photosynthetic electron transport in spinach chloroplasts. IC50 values of these compounds varied in wide range, from an intermediate to no inhibitory effect. 463 -1
$1 001 umb_un_cat*0293295 $1 011 $a 1420-3049 $1 200 1 $a Molecules $v Vol. 22, no. 6 (2017), pp. 1-11 $1 210 $a Basel $c Multidisciplinary Digital Publishing Institute $d 2017 606 0-
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$3 umb_un_auth*0133773 $a Šeršeň $b František $4 070 $9 15 701 -1
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Počet záznamov: 1